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Mol Nutr Food Res. 2014 Jun;58(6):1374-8. doi: 10.1002/mnfr.201300774. Epub 2014 Feb 24.

Hibiscus sabdariffa extract lowers blood pressure and improves endothelial function.

Author information

1
Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Campus of International Excellence Southern Catalonia, Reus, Spain.

Abstract

Polyphenols from Hibiscus sabdariffa calices were administered to patients with metabolic syndrome (125 mg/kg/day for 4 wk, n = 31) and spontaneously hypertensive rats (125 or 60 mg/kg in a single dose or daily for 1 wk, n = 8 for each experimental group). The H. sabdariffa extract improved metabolism, displayed potent anti-inflammatory and antioxidant activities, and significantly reduced blood pressure in both humans and rats. Diuresis and inhibition of the angiotensin I-converting enzyme were found to be less important mechanisms than those related to the antioxidant, anti-inflammatory, and endothelium-dependent effects to explain the beneficial actions. Notably, polyphenols induced a favorable endothelial response that should be considered in the management of metabolic cardiovascular risks.

KEYWORDS:

Diuresis; Hypertension; Inflammation; Oxidative stress; Phytochemicals

PMID:
24668839
DOI:
10.1002/mnfr.201300774
[Indexed for MEDLINE]

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