Send to

Choose Destination
See comment in PubMed Commons below
IUBMB Life. 2014 Apr;66(4):229-39. doi: 10.1002/iub.1262. Epub 2014 Mar 25.

Selenium and selenoprotein function in brain disorders.

Author information

Department of Cell and Molecular Biology, University of Hawaii, John A. Burns School of Medicine, Honolulu, HI, USA.


Selenoproteins are important for normal brain function, and decreased function of selenoproteins can lead to impaired cognitive function and neurological disorders. This review examines the possible roles of selenoproteins in Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and epilepsy. Selenium deficiency is associated with cognitive decline, and selenoproteins may be helpful in preventing neurodegeneration in AD. PD is associated with impaired function of glutathione peroxidase selenoenzymes. In HD, selenium deters lipid peroxidation by increasing specific glutathione peroxidases. Selenium deficiency increases risk of seizures in epilepsy, whereas supplementation may help to alleviate seizures. Further studies on the mechanisms of selenoprotein function will increase our understanding of how selenium and selenoproteins can be used in treatment and prevention of brain disorders.


Alzheimer's disease; Huntington's disease; Parkinson's disease; epilepsy; glutathione; glutathione peroxidase; phospholipid hydroperoxide glutathione peroxidase; selenium; selenoprotein; thioredoxin reductase

[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center