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Virulence. 2014 May 15;5(4):477-97. doi: 10.4161/viru.28595. Epub 2014 Mar 25.

Streptococcus suis infection: an emerging/reemerging challenge of bacterial infectious diseases?

Author information

1
Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases & State Key Laboratory for Diagnosis and Treatment of Infectious Disease; First Affiliated Hospital; Zhejiang University School of Medicine; Hangzhou, Zhejiang, PR China; Department of Medical Microbiology and Parasitology; Zhejiang University School of Medicine; Hangzhou, Zhejiang, PR China.
2
University of Illinois at Urbana-Champaign (UIUC); Urbana, IL USA.
3
Department of Veterinary Microbiology and Preventive Medicine; Iowa State University; Ames, IA USA.
4
College of Life Sciences; Fujian Agriculture and Forestry University; Fuzhou, Fujian, PR China.
5
Department of Epidemiology; Research Institute for Medicine of Nanjing Command; Nanjing, Jiangsu, PR China.

Abstract

Streptococcus suis (S. suis) is a family of pathogenic gram-positive bacterial strains that represents a primary health problem in the swine industry worldwide. S. suis is also an emerging zoonotic pathogen that causes severe human infections clinically featuring with varied diseases/syndromes (such as meningitis, septicemia, and arthritis). Over the past few decades, continued efforts have made significant progress toward better understanding this zoonotic infectious entity, contributing in part to the elucidation of the molecular mechanism underlying its high pathogenicity. This review is aimed at presenting an updated overview of this pathogen from the perspective of molecular epidemiology, clinical diagnosis and typing, virulence mechanism, and protective antigens contributing to its zoonosis.

KEYWORDS:

Streptococcus suis; pathogenesis; zoonosis

PMID:
24667807
PMCID:
PMC4063810
DOI:
10.4161/viru.28595
[Indexed for MEDLINE]
Free PMC Article

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