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Pain. 2014 Jul;155(7):1412-5. doi: 10.1016/j.pain.2014.03.014. Epub 2014 Mar 22.

Case report: Long-standing complex regional pain syndrome relieved by a cephalosporin antibiotic.

Author information

1
The Alan Edwards Pain Management Unit, McGill University Health Centre, McGill University, Montreal, Quebec, Canada; Department of Family Medicine, McGill University, Montreal, Quebec, Canada; The Louise and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada. Electronic address: mark.ware@mcgill.ca.
2
Department of Anesthesia, McGill University, Montreal, Quebec, Canada; Faculty of Dentistry, McGill University, Montreal, Quebec, Canada; The Louise and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada.

Abstract

We describe a young woman who had had treatment-refractory complex regional pain syndrome (CRPS) for 6 years before receiving antibiotic treatment with cefadroxil (a cephalosporin derivative) for a minor infection. Cefadroxil reduced the patient's pain and motor dysfunction (dystonia and impaired voluntary movement) within days; the pain and motor disorder returned when cefadroxil was discontinued; and both again abated when cefadroxil was re-instituted. The patient has now had symptom relief for more than 3 years on continuing cefadroxil therapy. We discuss this case in the context of previous reports of antibiotic treatment relieving neuropathic pain in experimental animals.

KEYWORDS:

CRPS; Cefadroxil; Ceftriaxone; Cephalosporin; Neuropathic pain; RSD

PMID:
24667741
DOI:
10.1016/j.pain.2014.03.014
[Indexed for MEDLINE]
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