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J Clin Gastroenterol. 2014 Aug;48(7):625-8. doi: 10.1097/MCG.0000000000000131.

Fecal microbiota transplantation inducing remission in Crohn's colitis and the associated changes in fecal microbial profile.

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1
*Department of Medicine, University of Alberta, Edmonton, AB †Department of Environmental Science and Policy, George Mason University, Manassa, VA.

Abstract

Inflammatory bowel disease (IBD) is a chronic relapsing disorder of the intestine of unclear etiology. Increasing evidence has pointed to intestinal dysbiosis as a potential factor in a genetically susceptible individual. Fecal microbiota transplantation (FMT) has been used to treat inflammatory bowel disease with variable degrees of success. Herein, we report a patient with Crohn's colitis, previously failing an immunosuppressant, who achieved clinical, endoscopic, and histologic remission after a single fecal microbiota transplantation infusion. We have further characterized the changes in the fecal microbiota associated with this observation.

PMID:
24667590
DOI:
10.1097/MCG.0000000000000131
[Indexed for MEDLINE]

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