Format

Send to

Choose Destination
Arch Oral Biol. 2014 May;59(5):550-8. doi: 10.1016/j.archoralbio.2014.02.004. Epub 2014 Feb 15.

Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) in rabbit-skull defect healing.

Author information

1
Department of Oral and Maxillofacial Surgery, Dental Research Institute, and Institute for Translational Dental Sciences, School of Dentistry, Pusan National University, Yangsan, South Korea.
2
Regea, BioMediTech, Institute of Biomedical Technology, University of Tampere, Tampere, Finland; Department of Oral and Maxillofacial Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland.
3
Department of Oral and Maxillofacial Surgery, Dental Research Institute, and Institute for Translational Dental Sciences, School of Dentistry, Pusan National University, Yangsan, South Korea. Electronic address: ydkimdds@pusan.ac.kr.

Abstract

OBJECTIVES:

The objective of this study was to evaluate the effect of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) on bone healing.

STUDY DESIGN:

Twelve rabbits were included in this randomized, blinded, prospective study. 15-mm×10-mm-sized defects were created in the parietal bone, filled with PRP, PRF, CGF, and void. The bone mineral density and bone volume were analyzed with microscopic computed tomography (micro-CT) and histomorphometrics at the 6th and 12th week.

RESULTS:

In micro-CT analysis, bone mineral density and bone volume were greater in the experimental group than in controls at both 6th and 12th week, but not among the experimental groups. Similarly, histomorphometric examination revealed that more bone formation was seen in the experimental group.

CONCLUSION:

The addition of PRP, PRF, and CGF had significantly increased bone formation at the 6th week. The effect of PRP, PRF, and CGF was similar and may be useful in the future to increase the success rate of bone grafting.

KEYWORDS:

Bone density; Bone graft; Bone volume; Cytokines; Histomorphometrics

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center