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Behav Brain Res. 2014 Jul 1;267:178-88. doi: 10.1016/j.bbr.2014.02.040. Epub 2014 Mar 22.

Luteolin protects against high fat diet-induced cognitive deficits in obesity mice.

Author information

  • 1Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: cbpe201087@gmail.com.
  • 2Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: cbpe201104@163.com.
  • 3Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: xinjingwutong@163.com.
  • 4Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: lisai0821@sina.com.
  • 5Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: zjingzlove@163.com.
  • 6Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: wszc0220@126.com.
  • 7Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: lc510520@126.com.
  • 8Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: dashanlidenanhaiwo@163.com.
  • 9Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China. Electronic address: tonghhuang@gmail.com.
  • 10Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu Province, China.

Abstract

The epidemic and experimental studies have confirmed that the obesity can lead to neuroinflammation, neurodegenerative diseases and adversely affect cognition. Despite the numerous elucidations on the impact of obesity on cognition decline, the contributors to the impairments in obesity remain unclear. Male C57BL/6J mice were fed either a control or high-fat diet (HFD) for 16 weeks and then randomized into four groups treated with their respective diets for 4 weeks including control diet (CD); control diet+luteolin (CDL); high-fat diet (HFD), high-fat diet+luteolin (HFDL). The dose of luteolin was 10mg/kg, oral. We showed that adding luteolin in high-fat diet can significantly reduce body weight gain, food intake and plasma cytokines as well as improving glucose metabolism of mice on HFD. Importantly, we showed that luteolin treatment had the effects of alleviating neuroinflammation, oxidative stress and neuronal insulin resistance in the mouse brain, restored blood adipocytokines level to normal. Furthermore, luteolin increased the level of brain-derived neurotrophic factor (BDNF), the action of synapsin I (SYP) and postsynaptic density protein 95 (PSD-95) in the cortex and hippocampus as to that the behavioral performance in Morris water maze (MWM) and step-through task were significantly improved. These results indicate a previously unrecognized potential of luteolin in alleviating obesity-induced cognitive impairment for type-2 diabetes mellitus and Alzheimer disease (AD).

Copyright © 2014 Elsevier B.V. All rights reserved.

KEYWORDS:

C57BL/6J mice; High-fat diet; Luteolin; Neuronal insulin resistance; Obesity; Synaptic plasticity

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