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Bone. 2014 Jul;64:1-7. doi: 10.1016/j.bone.2014.03.010. Epub 2014 Mar 22.

Procollagen type 1 amino-terminal propeptide (P1NP) and risk of hip fractures in elderly Norwegian men and women. A NOREPOS study.

Author information

  • 1Department of Internal Medicine, Innlandet Hospital Trust, Hamar, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address: trine.finnes@sykehuset-innlandet.no.
  • 2Department of Endocrinology, Oslo University Hospital, Oslo, Norway.
  • 3Faculty of Medicine, University of Oslo, Oslo, Norway; Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
  • 4Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Department of Rheumatology, Haukeland University Hospital, Bergen, Norway.
  • 5Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
  • 6Hormone Laboratory, Oslo University Hospital, Oslo, Norway.
  • 7Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.

Abstract

The current study aimed to assess a possible association between the bone turnover marker procollagen type 1 amino-terminal propeptide (P1NP) and future hip fractures in elderly Norwegian men and women and to elucidate the relation between P1NP, bone mineral density and 25-hydroxyvitamin D (25(OH)D). Men and women aged 71 to 77 from two population based health studies in Norway (1999-2001) were followed for a median period of 7.3 years with respect to hip fractures. The study was designed as a case-cohort study. P1NP and 25(OH)D were analysed in frozen serum samples obtained at baseline in hip fracture patients (n=340) and in randomly selected sex stratified sub-cohorts. Bone mineral density was measured by dual-energy X-ray absorptiometry (DXA) in a subset of participants. Cox proportional hazards regression with inverse probability weighting and robust variance was performed. No significant correlation between 25(OH)D and P1NP was found. A negative correlation between P1NP and BMD was observed in women (Rho=-0.36, p=0.001). A similar trend was observed in men. No association between quartiles of P1NP and rate of subsequent hip fractures was found. Spline analyses suggested a higher rate of hip fracture at P1NP levels above 60 μg/L in both men and women. A higher hip fracture rate, which was independent of BMD, was also indicated in women with very low levels of P1NP.

KEYWORDS:

Bone turnover marker; Elderly; Hip fractures; Osteoporosis; Procollagen type 1 amino-terminal propeptide

PMID:
24667179
DOI:
10.1016/j.bone.2014.03.010
[PubMed - indexed for MEDLINE]
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