Format

Send to

Choose Destination
Eur J Obstet Gynecol Reprod Biol. 2014 May;176:55-9. doi: 10.1016/j.ejogrb.2014.02.031. Epub 2014 Feb 28.

Recurrent miscarriage and birth sex ratio.

Author information

1
The Jessop Wing, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom; Center for Reproductive Medicine, Dalian Obstetrics & Gynecology Hospital, Dalian, China.
2
The Jessop Wing, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom; Center for Reproductive Medicine, Sir Run Run Shaw Hospital, Zhejiang University, China.
3
The Jessop Wing, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom.
4
St Mary's Hospital, London, United Kingdom.
5
The Jessop Wing, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom. Electronic address: tinchiu.li@gmail.com.

Abstract

OBJECTIVE:

To examine the relationship between birth sex ratio and unexplained recurrent miscarriage (RM).

STUDY DESIGN:

Retrospective, observational study including a total of 138 women with primary recurrent miscarriage (PRM) and 170 women with secondary recurrent miscarriage (SRM) in a tertiary referral recurrent miscarriage clinic between 1992 and 2010. The sex ratio of the first birth and subsequent birth were the main outcome measures.

RESULTS:

In women with SRM: (i) The male:female sex ratio of the first stillbirth was 10:2, significantly (OR=4.76) higher than the male:female sex ratio of 1.05 among all births in UK. (ii) When the first born was a male, the male:female sex ratio of the subsequent birth was 21:35, significantly (OR=0.57) lower than the sex ratio among the general population. (iii) A male firstborn did not affect the chance of a subsequent live-birth. The findings did not apply to sex ratio in primary RM.

CONCLUSION:

There was a subtle relationship between the sex of the first and subsequent births and secondary recurrent miscarriage, but not primary recurrent miscarriage.

KEYWORDS:

First birth; Recurrent miscarriage; Sex ratio; Stillbirth; Subsequent birth

PMID:
24666800
DOI:
10.1016/j.ejogrb.2014.02.031
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center