Format

Send to

Choose Destination
J Integr Med. 2014 Mar;12(2):115-20. doi: 10.1016/S2095-4964(14)60011-X.

Protective effect of ginger volatile oil against acetic acid-induced colitis in rats: a light microscopic evaluation.

Author information

1
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2
Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
3
Department of Clinical Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
4
Department of Pharmacology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
5
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran; E-mail: minaiyan@pharm.mui.ac.ir.

Abstract

OBJECTIVE:

Ulcerative colitis is a chronically recurrent inflammatory bowel disease of unknown origin. In the present study, the effect of ginger (rhizome of Zingiber officinale Roscoe) volatile oil on a rat model of colitis was evaluated.

METHODS:

Volatile oil of ginger with doses of 100, 200, and 400 mg/kg, prednisolone (4 mg/kg), or vehicle were administered orally to groups of male Wistar rats (n = 6) for 5 d. Animals were randomly divided into 6 groups, each group consisting of 6 rats. Colitis was induced by intracolonic instillation of 2 mL of 4% (v/v) acetic acid solution. All rats were sacrificed 24 h later and the tissue injuries were assessed macroscopically and histopathologically.

RESULTS:

Ginger volatile oil with all doses reduced colon weight/length ratio (P < 0.01) and the effects were similar to the reference drugs. Higher oral doses of volatile oil (200 and 400 mg/kg) reduced ulcer severity (P < 0.05 and P < 0.01), ulcer area (P < 0.01) and ulcer index (P < 0.01). On the other hand, evaluation of microscopic scores showed that the dose of 400 mg/kg of volatile oil was effective to reduce inflammation severity (P < 0.01) and inflammation extent (P < 0.05) compared to the control group.

CONCLUSION:

It is concluded that ginger volatile oil could effectively reduce symptoms of experimental colitis in a dose-dependent manner.

PMID:
24666677
DOI:
10.1016/S2095-4964(14)60011-X
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center