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Tissue Barriers. 2013 Jul 1;1(3):e25391. doi: 10.4161/tisb.25391. Epub 2013 Jun 19.

Claudins in teleost fishes.

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1
Department of Biology; York University; Toronto, ON, Canada.

Abstract

Teleost fishes are a large and diverse animal group that represent close to 50% of all described vertebrate species. This review consolidates what is known about the claudin (Cldn) family of tight junction (TJ) proteins in teleosts. Cldns are transmembrane proteins of the vertebrate epithelial/endothelial TJ complex that largely determine TJ permeability. Cldns achieve this by expressing barrier or pore forming properties and by exhibiting distinct tissue distribution patterns. So far, ~63 genes encoding for Cldn TJ proteins have been reported in 16 teleost species. Collectively, cldns (or Cldns) are found in a broad array of teleost fish tissues, but select genes exhibit restricted expression patterns. Evidence to date strongly supports the view that Cldns play a vital role in the embryonic development of teleost fishes and in the physiology of tissues and organ systems studied thus far.

KEYWORDS:

Fugu; Tetraodon; claudin; epithelium; paracellular permeability; teleost fish; tight junction; whole genome duplication; zebrafish

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