Format

Send to

Choose Destination
See comment in PubMed Commons below
Tissue Barriers. 2013 Jul 1;1(3):e24782. doi: 10.4161/tisb.24782. Epub 2013 May 30.

Regulation of claudins in blood-tissue barriers under physiological and pathological states.

Author information

1
Laboratory of Pharmacology and Experimental Therapeutics; IBILI - Institute for Biomedical Imaging and Life Sciences; Faculty of Medicine; University of Coimbra; Coimbra, Portugal.
2
Centre of Ophthalmology and Vision Sciences; IBILI; Faculty of Medicine; University of Coimbra; Coimbra, Portugal ; AIBILI; Coimbra, Portugal.
3
Laboratory of Pharmacology and Experimental Therapeutics; IBILI - Institute for Biomedical Imaging and Life Sciences; Faculty of Medicine; University of Coimbra; Coimbra, Portugal ; Centre of Ophthalmology and Vision Sciences; IBILI; Faculty of Medicine; University of Coimbra; Coimbra, Portugal.

Abstract

Claudins are pivotal building blocks of tight junctions that form the paracellular barrier in epithelia and endothelia. In mammals, claudins are a 27-gene family that encodes tetraspan membrane proteins, playing a crucial role in the formation and integrity of tight junctions and regulate the barrier function. Claudin isoforms are expressed in a tissue- and/or developmental stage-dependent manner. A growing body of evidence indicates that pathological states characterized by neuroinflammation, such as Alzheimer disease, multiple sclerosis, diabetic retinopathy and retinopathy of prematurity share a common feature: the barrier breakdown. This review aims integrating and summarizing the most relevant and recent work developed in the field of claudins, with particular attention to their role in blood-brain and blood-retinal barriers, as well as describing their regulation in the aforementioned human diseases.

KEYWORDS:

blood-brain barrier; blood-retinal barrier; claudins; paracellular transport; tight junctions

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Support Center