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Int J Physiol Pathophysiol Pharmacol. 2014 Mar 13;6(1):23-36. eCollection 2014.

Evening primrose oil ameliorates platelet aggregation and improves cardiac recovery in myocardial-infarct hypercholesterolemic rats.

Author information

1
Department of Physiology, Faculty of Medicine, Suez Canal University Ismailia 41522, Egypt.
2
Department of Pharmacology, Faculty of Medicine, Suez Canal University Ismailia 41522, Egypt.

Abstract

Omega-6 polyunsaturated fatty acids (n-6 PUFA) are well known for their role in cardiovascular disease (CVD). We proposed that Evening prime rose oil (EPO) can improve the outcome of a heart with myocardial infarction (MI) in the presence of diet-induced hyperaggregability. This study was designed to examine its cholesterol lowering, antithrombotic and anti-inflammatory effects. High fat diet was administered for 4 weeks then MI was induced by isoproterenol (85 mg/kg/s.c./24 h). Treatment with EPO (5 or 10 gm/kg/day) for 6 weeks improved the electrocardiographic pattern, serum lipid profile, cardiac biomarkers as well as Platelet aggregation percent. We reported decreased serum level of TNF-α, IL-6 and COX-2 with attenuation of TNF-α and TGF-β in the cardiac homogenate. Moreover, histopathology revealed marked amelioration. Finally, we provide evidence that EPO improve cardiac recovery in hypercholesterolemic myocardial infarct rats. These effects are attributed to direct hypocholesterolemic effect and indirect effect on the synthesis of eicosanoids (prostaglandins, cytokines).

KEYWORDS:

Hypercholesterolemia; evening primrose oil; high fat diet; myocardial infarction

PMID:
24665356
PMCID:
PMC3961099

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