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Neurosci Bull. 2014 Apr;30(2):271-81. doi: 10.1007/s12264-013-1423-y. Epub 2014 Mar 24.

Oxidative stress in Alzheimer's disease.

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1
Department of Neurology, Zhongshan Hospital; The State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200032, China.

Abstract

Oxidative stress plays a significant role in the pathogenesis of Alzheimer's disease (AD), a devastating disease of the elderly. The brain is more vulnerable than other organs to oxidative stress, and most of the components of neurons (lipids, proteins, and nucleic acids) can be oxidized in AD due to mitochondrial dysfunction, increased metal levels, inflammation, and β-amyloid (Aβ) peptides. Oxidative stress participates in the development of AD by promoting Aβ deposition, tau hyperphosphorylation, and the subsequent loss of synapses and neurons. The relationship between oxidative stress and AD suggests that oxidative stress is an essential part of the pathological process, and antioxidants may be useful for AD treatment.

PMID:
24664866
PMCID:
PMC5562667
DOI:
10.1007/s12264-013-1423-y
[Indexed for MEDLINE]
Free PMC Article
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