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J Neurooncol. 2014 Jun;118(2):289-296. doi: 10.1007/s11060-014-1423-4. Epub 2014 Mar 25.

Karyopherin a2 and chromosome region maintenance protein 1 expression in meningiomas: novel biomarkers for recurrence and malignant progression.

Author information

1
Department of Neurosurgery, University Hospital of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany. kostasgousias@yahoo.com.
2
Department of Neuropathology, University Hospital of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany.
3
Department of Neurosurgery, University Hospital of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany.

Abstract

The karyopherin protein family comprises importins and exportins which are nucleocytoplasmic shuttling receptors. Increased levels of karyopherin a2 and chromosome region maintenance protein 1 correlate with a higher WHO grade and a poorer prognosis in patients with infiltrative astrocytomas. The aim of this study was to evaluate representative members of importins and exportins (i.e. karyopherin a2 and chromosome region maintenance protein 1) as novel biomarkers for meningiomas of WHO grades I-III. We semiquantitatively analyzed nuclear expression of karyopherin a2, chromosome region maintenance protein 1 and the MIB1 labeling index using immunohistochemistry in 108 primary (44 meningiomas WHO grade I, 48 meningiomas WHO grade II, 16 meningiomas WHO grade III) and 13 recurrent meningiomas. Statistical analysis was performed using standard techniques. Karyopherin a2 (p < 0.001) and chromosome region maintenance protein 1 (p = 0.002) expression correlated significantly with the histological grade. Karyopherin a2 expression correlated with proliferative activity as assessed by the MIB1 index (p < 0.001). Recurrent tumors expressed significantly higher levels of karyopherin a2 (p = 0.045) when compared to primary growths. Multivariate analysis of the overall series as well as of patients with atypical meningiomas identified higher karyopherin a2 (≥ 5 vs. <5%) and chromosome region maintenance protein 1 (≥ 60 vs. 60%) expression as independent predictors of tumor recurrence. Karyopherin a2 and chromosome region maintenance protein 1 expression may have potential as novel biomarkers for meningiomas.

PMID:
24664371
DOI:
10.1007/s11060-014-1423-4
[Indexed for MEDLINE]

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