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Chem Commun (Camb). 2014 May 4;50(34):4504-7. doi: 10.1039/c4cc00144c. Epub 2014 Mar 25.

Red Si-rhodamine drug conjugates enable imaging in GFP cells.

Author information

1
Center for Systems Biology, Massachusettes General Hospital/Harvard Medical School, 185 Cambridge St, Boston, MA 02114, USA. rweissleder@mgh.harvard.edu.

Abstract

Here we evaluated a series of Si-derivatized rhodamine (SiR) dyes for their ability to visualize a model drug in live cells. We show that a charge neutral SiR derivative (but not others) can indeed be used to follow the intracellular location of the model therapeutic drug in GFP cells.

PMID:
24663433
PMCID:
PMC4028821
DOI:
10.1039/c4cc00144c
[Indexed for MEDLINE]
Free PMC Article

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