Format

Send to

Choose Destination
Circ Res. 2014 May 9;114(10):1569-75. doi: 10.1161/CIRCRESAHA.114.303915. Epub 2014 Mar 24.

Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure.

Author information

1
From the Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx (R.K., I.V., J.F., A.H., T.T.) and REBIRTH Excellence Cluster (T.T.), Hannover Medical School, Hannover, Germany; Inserm, U744, University Lille Nord de France, Lille, France (C.B., F.M., G.L., P.d.G., F.P.); Institut Pasteur de Lille, Lille, France (C.B., F.M., G.L., P.d.G., F.P.); Centre Hospitalier Régional et Universitaire de Lille, Lille, France (C.B., G.L., P.d.G., F.P.); Faculté de Médecine de Lille, Lille, France (C.B., G.L.); and National Heart and Lung Institute, Imperial College London, London, United Kingdom (T.T.).

Abstract

RATIONALE:

Long noncoding RNAs represent a novel class of molecules regulating gene expression. Long noncoding RNAs are present in body fluids, but their potential as biomarkers was never investigated in cardiovascular disease.

OBJECTIVE:

To study the role of long noncoding RNAs as potential biomarkers in heart disease.

METHODS AND RESULTS:

Global transcriptomic analyses were done in plasma RNA from patients with or without left ventricular remodeling after myocardial infarction. Regulated candidates were validated in 3 independent patient cohorts developing cardiac remodeling and heart failure (788 patients). The mitochondrial long noncoding RNA uc022bqs.1 (LIPCAR) was downregulated early after myocardial infarction but upregulated during later stages. LIPCAR levels identified patients developing cardiac remodeling and were independently to other risk markers associated with future cardiovascular deaths.

CONCLUSIONS:

LIPCAR is a novel biomarker of cardiac remodeling and predicts future death in patients with heart failure.

KEYWORDS:

RNA, long noncoding; cardiac biomarkers; cardiac remodeling; circulating lncRNA; heart failure; mitochondria; myocardial infarction

PMID:
24663402
DOI:
10.1161/CIRCRESAHA.114.303915
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center