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Cancer Epidemiol Biomarkers Prev. 2014 Jun;23(6):1125-8. doi: 10.1158/1055-9965.EPI-13-1354. Epub 2014 Mar 24.

GWAS-identified common variants for obesity are not associated with the risk of developing colorectal cancer.

Author information

1
Authors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
2
Authors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, SwedenAuthors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
3
Authors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, SwedenAuthors' Affiliations: Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden A.Foersti@dkfz-heidelberg.de.

Abstract

BACKGROUND:

Observational studies have consistently associated obesity with colorectal cancer risk. Because both traits are genetically determined and share some metabolic biomarkers, we hypothesized that obesity-related polymorphisms could also influence the risk of developing colorectal cancer.

METHODS:

We conducted a comprehensive population-based case-control study in 1,792 German colorectal cancer cases and 1,805 controls to explore associations between 28 obesogenic variants identified through genome-wide association studies (GWAS) and colorectal cancer risk. We also evaluated interactions between polymorphisms and body mass index (BMI), type II diabetes (T2D), and gender.

RESULTS:

No evidence of association between obesogenic variants and colorectal cancer risk was observed after correction for multiple testing. There was only a remarkable interaction between the LTArs1041981 polymorphism and gender, which modified the risk of colorectal cancer [Pinteraction = 0.002; males: odds ratio (OR), 1.14; 95% confidence intervals (CI), 1.00-1.30 vs. females: OR, 0.83; 95% CI, 0.71-0.97].

CONCLUSIONS:

Our findings showed that obesogenic variants are not a major pathogenetic risk factor for colorectal cancer.

IMPACT:

This comprehensive population-based case-control study does not provide evidence of a shared genetic component between obesity and colorectal cancer.

PMID:
24663336
DOI:
10.1158/1055-9965.EPI-13-1354
[Indexed for MEDLINE]
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