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PLoS One. 2014 Mar 24;9(3):e92607. doi: 10.1371/journal.pone.0092607. eCollection 2014.

Association between sleep quality and C-reactive protein: results from national health and nutrition examination survey, 2005-2008.

Author information

1
Beijing An Zhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China; Mary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago and Children's Hospital of Chicago Research Center, Chicago, Illinois, United States of America.
2
Mary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago and Children's Hospital of Chicago Research Center, Chicago, Illinois, United States of America.
3
Department of Neurology and Sleep Medicine Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
4
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
5
Department of Neurobiology, Beijing Institute of Geriatrics, Beijing Xuan Wu Hospital, Capital Medical University, Beijing, China.
6
Department of Otorhinolaryngology, Beijing An Zhen Hospital, Capital Medical University, Beijing, China.
7
Beijing An Zhen Hospital, Capital Medical University, The Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.

Abstract

OBJECTIVE:

Our objective was to explore the association between poor sleep quality and hs_CRP in an adult U.S. population.

METHODS:

This study focused on 9,317 participants in the National Health and Nutrition Examination Survey (NHANES) from 2005-2008 who were aged 20-85 years, completed a sleep disorder questionnaire, and had available information on serum hs_CRP. Sleep quality was classified into three categories (good, moderate, poor) based on the responses of participants to the NHANES sleep disorder questionnaire. High CRP was defined as hs-CRP >1 md/dL. Linear regression model was applied to investigate the association between poor sleep quality and log-transformed hs_CRP. And logistic regression model was fitted to evaluate the association between sleep quality and the risk of high CRP.

RESULTS:

Females were more likely to report poor sleep quality than males (26% vs. 19%, p<0.0001). Each sleep disorder was significantly associated with increased hs_CRP and correlative to other sleep disorders. In fully-adjusted linear regression model, poor sleep quality was significantly associated with elevated hs_CRP (log transformed) among the overall sample and in females only (β = 0.10, se = 0.03, p<0.01 and β = 0.13, se = 0.04, p<0.01, respectively). In fully-adjusted logistics regression model, poor sleep quality was linked with risk of high CRP(OR: 1.42, 95%CI: 1.15-1.76 in overall sample and OR: 1.59, 95%CI: 1.18-2.14 in females, respectively).

CONCLUSION:

We found that poor sleep quality was independently associated with elevated hs_CRP in females but not in males in a U.S. adult population.

PMID:
24663098
PMCID:
PMC3963926
DOI:
10.1371/journal.pone.0092607
[Indexed for MEDLINE]
Free PMC Article

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