Format

Send to

Choose Destination
See comment in PubMed Commons below
J Thorac Oncol. 2014 May;9(5):639-45. doi: 10.1097/JTO.0000000000000144.

Correlation of regional emphysema and lung cancer: a lung tissue research consortium-based study.

Author information

1
*Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester; †Department of Biostatistics and Informatics, Mayo Clinic, Rochester; ‡Department of Radiology; §Department of Epidemiology, Mayo Clinic, Rochester; ‖Division of Pulmonary and Critical Care Medicine and VAMC, University of Minnesota Medical School, Minneapolis, MN; ¶Division of Pulmonary and Critical Care Medicine, University of Minnesota Medical School, Minneapolis, MN; and #Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.

Abstract

BACKGROUND:

Chronic obstructive pulmonary disease and lung cancer are linked because both airflow obstruction and emphysema, on computer tomography, are independent risk factors for lung cancer. However, the local risk of malignancy relative to development of regional emphysema has not yet been defined. Specifically, it is not known if primary lung cancers are associated with regions of worse emphysema within individual patients.

METHODS:

We performed a database analysis evaluating the association between the degree of regional emphysema as scored on computer tomography and development of primary lung cancer. We also studied the association between regional emphysema and benign lung nodules. We assembled two distinct cohorts using the National Heart, Lung, and Blood Institute's Lung Tissue Research Consortium database, hypothesizing that lung malignancy will preferentially locate in the regions of the most severe emphysema.

RESULTS:

In the Lung Tissue Research Consortium database, 624 cases met criteria for the malignant nodule cohort and 64 were included in the benign nodule cohort. When comparing location of a malignant nodule to other lung regions within the same person, the odds of having a more severe emphysema score in the location of lung cancer was 1.342 (95% confidence interval 1.112-1.620; p = 0.0022). When comparing location of a benign nodule to other lung regions within the same person, the odds of having a more severe emphysema score in the location of the benign nodule was 1.118 (95% confidence interval 0.725-1.725; p = 0.6137).

CONCLUSIONS:

Primary lung cancers are associated with areas of worse regional emphysema.

PMID:
24662456
PMCID:
PMC3984592
DOI:
10.1097/JTO.0000000000000144
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center