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J Acquir Immune Defic Syndr. 2014 Jun 1;66(2):188-92. doi: 10.1097/QAI.0000000000000130.

Factors associated with recurrence of cervical intraepithelial neoplasia 2+ after treatment among HIV-infected women in Western Kenya.

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1
*Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA; †Department of Epidemiology, University of California, Berkeley, CA; ‡Kenya Medical Research Institute, Nairobi, Kenya; and §.

Abstract

HIV-infected women are at increased risk for recurrence of cervical dysplasia after treatment. Short-term recurrence rates may reflect treatment efficacy and therefore impact screening protocols and follow-up planning. We conducted a prospective study of 297 HIV-infected women undergoing loop electrosurgical excision procedure for cervical intraepithelial neoplasia 2+ (CIN2+) in an HIV clinic in Kisumu, Kenya. By 6 months after the procedure, 20 (7.1%) of women had recurrent CIN2+. Recurrence was significantly associated with CD4 nadir but not with highly active antiretroviral therapy use. Longer-term follow-up of this cohort will illustrate the potential impact of highly active antiretroviral therapy and immune status on CIN2/3 disease recurrence.

PMID:
24662299
PMCID:
PMC4166547
DOI:
10.1097/QAI.0000000000000130
[Indexed for MEDLINE]
Free PMC Article
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