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Nat Rev Genet. 2014 May;15(5):293-306. doi: 10.1038/nrg3724. Epub 2014 Mar 25.

Gene expression regulation mediated through reversible m⁶A RNA methylation.

Author information

1
Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.
2
1] Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA. [2] Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel. [3] Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
3
1] Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel. [2] Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Abstract

Cellular RNAs carry diverse chemical modifications that used to be regarded as static and having minor roles in 'fine-tuning' structural and functional properties of RNAs. In this Review, we focus on reversible methylation through the most prevalent mammalian mRNA internal modification, N(6)-methyladenosine (m(6)A). Recent studies have discovered protein 'writers', 'erasers' and 'readers' of this RNA chemical mark, as well as its dynamic deposition on mRNA and other types of nuclear RNA. These findings strongly indicate dynamic regulatory roles that are analogous to the well-known reversible epigenetic modifications of DNA and histone proteins. This reversible RNA methylation adds a new dimension to the developing picture of post-transcriptional regulation of gene expression.

PMID:
24662220
DOI:
10.1038/nrg3724
[Indexed for MEDLINE]

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