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Molecules. 2014 Mar 24;19(3):3607-16. doi: 10.3390/molecules19033607.

Antimicrobial activities against periodontopathic bacteria of Pittosporum tobira and its active compound.

Author information

1
Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Kyunghee Daero 26, Dongdaemungu, Seoul 130-701, Korea.
2
Department of Life Science, Gachon University, Seongnam Daero 1342, Seongnam, Gyeonggi-Do 461-701, Korea.
3
Department of Life Science, Gachon University, Seongnam Daero 1342, Seongnam, Gyeonggi-Do 461-701, Korea. sckang73@gachon.ac.kr.
4
Department of Biological & Environmental Science, Dongguk University, Pildongro-1gil 30, Junggu, Seoul 100-715, Korea.
5
Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Kyunghee Daero 26, Dongdaemungu, Seoul 130-701, Korea. ljinyong@khu.ac.kr.

Abstract

The study of medicinal plants for treatment of periodontitis is of great value to establish their efficacy as sources of new antimicrobial drugs. Five hundred and fifty eight Korean local plant extracts were screened for antibacterial activity against representative periodontopathic bacteria such as Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum. Among the various medicinal plants, the alcohol extract of Pittosporum tobira, which significantly exhibited antibacterial effect for all tested strains, showed the highest activity in the antimicrobial assays. NMR analyses revealed that R1-barrigenol, a triterpene sapogenin, was the most effective compound in P. tobira. These results demonstrated that P. tobira possesses antimicrobial properties and would be beneficial for the prevention and treatment of periodontitis.

PMID:
24662076
DOI:
10.3390/molecules19033607
[Indexed for MEDLINE]
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