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Diabetes Metab Syndr. 2014 Jan-Mar;8(1):3-7. doi: 10.1016/j.dsx.2013.10.005. Epub 2013 Nov 21.

Adiponectin and waist circumference as predictors of insulin-resistance in women.

Author information

1
Ministerio de Salud Pública de la Provincia de Misiones, Argentina; Facultad de Ciencias Exactas, Químicas y Naturales, Universidad Nacional de Misiones, Argentina. Electronic address: gracielabonneau@yahoo.com.ar.
2
Ministerio de Salud Pública de la Provincia de Misiones, Argentina.
3
Lipids and Lipoproteins Laboratory, Faculty of Pharmacy and Biochemistry, INFIBIOC, University of Buenos Aires, Argentina.

Abstract

BACKGROUND AND AIMS:

The initial disturbance of insulin resistance seems to focus on adipose tissue is a dynamic organ involved in many physiological and metabolic processes. Expresses and secretes a variety of active peptides, adipocytokines. To evaluate the prevalence of insulin-resistance in an healthy urban middle age population and to explore the role of adiponectin, inflammatory biomarkers (hs-CRP) and traditional cardiovascular risk factors as predictors of the insulin-resistance state.

MATERIALS AND METHODS:

We studied of 176 participants (117 women and 59 men, 25-74 years), individuals with diabetes, hypothyroidism or hyperthyroidism, infectious disease, renal, or hepatic neoplasms and pregnant women were excluded. We evaluated glucose, insulin, adiponectin and hs-CRP.

RESULTS:

We found that 17.2% of individuals presented insulin-resistance. Correlation was found between waist circumference, body mass index, blood pressure and HOMA index (p<0.01). Adiponectin was associated with the insulin-resistance (p<0.001) but not hs-CRP. Adiponectin (β=0.385, p=0.004) and waist circumference (β=0.116, p=0.02) were predictors of IR only in women, meanwhile none of the analyzed biomarkers predicted insulin-resistance in men. Besides, postmenopausal women presented higher adiponectin levels than premenopausal 7.63 (4.46-9.58) vs 5.50 (3.83-7.40) μg/ml, p=0.01.

CONCLUSIONS:

Adiponectin and waist circumference are important predictors of insulin-resistance even in healthy non-diabetic women, they may open a new opportunity to improve current risk estimation.

KEYWORDS:

Abdominal obesity; Adiponectin; Female gender; Insulin-resistance; Post-menopause

PMID:
24661750
DOI:
10.1016/j.dsx.2013.10.005
[Indexed for MEDLINE]

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