[Cisplatin, vinblastine, and bleomycin combination chemotherapy in a stage IV pure endodermal sinus tumor of the ovary--a case report of a long-term survival]

Gan No Rinsho. 1988 Dec;34(15):2114-8.
[Article in Japanese]

Abstract

Discussed is a case of a stage IV pure endodermal sinus tumor (EST) of the ovary that was treated with a PVB protocol following cytoreductive surgery. The serum alpha-fetoprotein (AFP) dosage before treatment was 83,546 ng/ml, and a complete clinical response was achieved with the disappearance of pleural effusions, ascites, and normalization of the serum AFP. A second-look laparotomy was substituted by serial AFP determinations and the patient remained free of disease for two years. Recently, complete remissions and long term survivals of patients with a stage I-II disease have been reported, though a prolonged or a complete remission of a stage IV EST of the ovary is still a rarity.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bleomycin / administration & dosage
  • Cisplatin / administration & dosage
  • Combined Modality Therapy
  • Drug Administration Schedule
  • Female
  • Humans
  • Mesonephroma / drug therapy*
  • Mesonephroma / pathology
  • Mesonephroma / surgery
  • Neoplasm Staging
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / surgery
  • Prognosis
  • Remission Induction
  • Vinblastine / administration & dosage
  • alpha-Fetoproteins / analysis

Substances

  • alpha-Fetoproteins
  • Bleomycin
  • Vinblastine
  • Cisplatin

Supplementary concepts

  • PVB protocol