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Anesth Pain Med. 2013 Dec 26;4(1):e9997. doi: 10.5812/aapm.9997. eCollection 2014 Feb.

Analgesic Efficacy of Diclofenac and Paracetamol vs. Meperidine in Cesarean Section.

Author information

1
Anesthesiology Department, Amiralmomenin Hospital, Islamic Azad University, Tehran Medical Branch, Tehran, IR Iran.
2
Department of Medical Researches, Islamic Azad University, Tehran Medical Branch, Tehran, Iran.
3
Department of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

BACKGROUND:

One of the most important complications in cesarean surgery is postoperative pain, and different ways have been proposed to control it.

OBJECTIVES:

The purpose of this study was to determine the efficacy of Diclofenac and Paracetamol combination in comparison with Meperidine on postoperative pain after cesarean surgery.

PATIENTS AND METHODS:

One hundred and twenty women candidates for elective cesarean section under spinal anesthesia categorized as ASA class I were selected and randomly assigned to receive either Diclofenac suppository at the end of the operation and thereafter 1 gram infused bolus of Paracetamol (group A), or 20 mg bolus of Meperidine after transition to recovery room (group B) to control postoperative pain.

RESULTS:

Postoperative pain was present in recovery in 38.3% and 23.3% in groups B and A, respectively (P = 0.009). Postoperative pain was seen after six hours of operation in 38.7% and 16.7% in groups B and A, respectively (P = 0.010). Postoperative pain was present after 12 hours of operation in 38.3% and 15% in groups B and A, respectively (P = 0.002). The additive Meperidine use was the same between the two groups in recovery (P > 0.05). The additive Meperidine use was seen after six hours of operation in 26.7% and 6.7% in groups B and A, respectively (P = 0.013). The additive Meperidine use was seen after 12 hours of operation in 16.7% and none of the patients in groups B and A, respectively (P = 0.004). The frequency of drug adverse effects was the same between the two groups (P > 0.05).

CONCLUSIONS:

Totally, according to the obtained results it may be concluded that Paracetamol and Diclofenac combination would have a better efficacy in postoperative pain control and need reduction to additive analgesia compared to Meperidine.

KEYWORDS:

Acetaminophen; Cesarean Section; Diclofenac; Meperidine; Pain, Postoperative

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