Send to

Choose Destination
See comment in PubMed Commons below
Front Plant Sci. 2014 Mar 13;5:83. doi: 10.3389/fpls.2014.00083. eCollection 2014.

Dynamic regulation and function of histone monoubiquitination in plants.

Author information

  • 1Institut de Biologie Moléculaire des Plantes, UPR2357 CNRS, Université de Strasbourg Strasbourg, France.


Polyubiquitin chain deposition on a target protein frequently leads to proteasome-mediated degradation whereas monoubiquitination modifies target protein property and function independent of proteolysis. Histone monoubiquitination occurs in chromatin and is in nowadays recognized as one critical type of epigenetic marks in eukaryotes. While H2A monoubiquitination (H2Aub1) is generally associated with transcription repression mediated by the Polycomb pathway, H2Bub1 is involved in transcription activation. H2Aub1 and H2Bub1 levels are dynamically regulated via deposition and removal by specific enzymes. We review knows and unknowns of dynamic regulation of H2Aub1 and H2Bub1 deposition and removal in plants and highlight the underlying crucial functions in gene transcription, cell proliferation/differentiation, and plant growth and development. We also discuss crosstalks existing between H2Aub1 or H2Bub1 and different histone methylations for an ample mechanistic understanding.


Arabidopsis thaliana; chromatin; epigenetics; histone monoubiquitination; plant development; transcription regulation; ubiquitin

Publication Types

Publication Types

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Write to the Help Desk