Format

Send to

Choose Destination
See comment in PubMed Commons below
Diab Vasc Dis Res. 2014 May;11(3):201-7. doi: 10.1177/1479164114525971. Epub 2014 Mar 21.

Test-retest reliability of peripheral arterial tonometry in the metabolic syndrome.

Author information

1
Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA.

Abstract

Endothelial dysfunction is an important contributor to atherosclerosis and cardiovascular disease. However, routine assessment via angiography or flow-mediated dilation is difficult due to technical limitations. Peripheral arterial tonometry (PAT) is a promising alternative method for non-invasive assessment of endothelial dysfunction. This study assessed the test-retest reliability of PAT in adults with the metabolic syndrome (n = 20) and provides sample size and power estimates for study design. Participants completed five PAT tests each separated by 1 week. The PAT-derived reactive hyperaemia index (RHI) showed robust repeatability (intra-class correlation = 0.74). A parallel-arm study powered at 0.90 would require 22 participants to detect an absolute change in RHI of 0.40 units (equal to ~25% change in this sample), whereas a crossover study would require 12 participants. In conclusion, we have demonstrated that PAT can be used to assess endothelial dysfunction in adults with the metabolic syndrome as reliably as in healthy samples.

KEYWORDS:

Peripheral arterial tonometry; endothelial function; metabolic syndrome; reliability

PMID:
24659234
PMCID:
PMC4419826
DOI:
10.1177/1479164114525971
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Support Center