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J Clin Lab Anal. 2014 Nov;28(6):461-4. doi: 10.1002/jcla.21710. Epub 2014 Mar 22.

Association of promoter genetic variants in interleukin-10 and Kawasaki disease with coronary artery aneurysms.

Author information

1
Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan.

Abstract

BACKGROUND:

Kawasaki disease (KD) is an acute, self-limited vasculitis in infants and young children. Interleukin-10 (IL-10) is a potent cytokine that exerts pleiotropic effects on immunoregulation and inflammation. Elevated IL-10 serum levels have been reported in the KD patients.

METHODS:

In this study, we investigated whether IL-10 genetic polymorphisms contribute to coronary artery aneurysm (CAA) development among KD patients in Taiwan. A total of 58 KD patients with CAA and 277 unrelated healthy children matched for sex and age were enrolled for this study.

RESULTS:

Higher G allele frequencies of IL-10 at -1082 position were observed in KD patients with CAA compared to the controls (P = 0.016, OR: 2.86, 95% CI, 1.17-6.98). In addition, higher IL-10 GCC haplotype frequencies were also observed in KD patients with CAA (P = 0.016, OR: 2.85, 95% CI, 1.17-6.98).

CONCLUSION:

Our data support the possibility that IL-10 gene polymorphisms may be related with CAA development of KD in Taiwanese population.

KEYWORDS:

Kawasaki disease; coronary artery aneurysms; genetic polymorphism; interleukin-10

PMID:
24659220
DOI:
10.1002/jcla.21710
[Indexed for MEDLINE]

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