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PLoS One. 2014 Mar 21;9(3):e92920. doi: 10.1371/journal.pone.0092920. eCollection 2014.

The IclR-family regulator BapR controls biofilm formation in B. cenocepacia H111.

Author information

1
Department of Microbiology, Institute of Plant Biology, University of Zurich, Zurich, Switzerland.

Abstract

In Burkholderia cenocepacia H111, the large surface protein BapA plays a crucial role in the formation of highly structured communities, known as biofilms. We have recently demonstrated that quorum sensing (QS) is necessary for the maximal expression of bapA. In this study we identify BapR, a protein from the IclR family of transcriptional regulators that, in conjunction with QS, controls biofilm formation by affecting the expression of bapA. We present evidence that, in addition to bapA, BapR influences the expression of extracellular proteases, swimming motility and has a profound impact in the incidence of persister cells, making this regulator an interesting target for persister cells and biofilm eradication.

PMID:
24658785
PMCID:
PMC3962473
DOI:
10.1371/journal.pone.0092920
[Indexed for MEDLINE]
Free PMC Article

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