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Curr Opin Biotechnol. 2014 Oct;29:62-9. doi: 10.1016/j.copbio.2014.02.015. Epub 2014 Mar 20.

Processing of recombinant spider silk proteins into tailor-made materials for biomaterials applications.

Author information

1
Lehrstuhl Biomaterialien, Fakultät für Ingenieurwissenschaften, Universität Bayreuth, Universitätsstraße 30, Bayreuth 95440, Germany.
2
Lehrstuhl Biomaterialien, Fakultät für Ingenieurwissenschaften, Universität Bayreuth, Universitätsstraße 30, Bayreuth 95440, Germany; Bayreuther Zentrum für Kolloide und Grenzflächen (BZKG), Universität Bayreuth, Universitätsstraße 30, Bayreuth 95440, Germany; Institut für Bio-Makromoleküle (bio-mac), Universität Bayreuth, Universitätsstraße 30, Bayreuth 95440, Germany; Bayreuther Zentrum für Molekulare Biowissenschaften (BZMB), Universität Bayreuth, Universitätsstraße 30, Bayreuth 95440, Germany; Bayreuther Materialzentrum (BayMAT), Universität Bayreuth, Universitätsstraße 30, Bayreuth 95440, Germany. Electronic address: Thomas.Scheibel@uni-bayreuth.de.

Abstract

Spider silk has extraordinary mechanical properties, is biocompatible and biodegradable, and therefore an ideal material for biomedical applications. However, a drawback for any application is the inhomogeneity of spider silk, as seen for other natural materials, as well as the low availability due to the cannibalism of most spiders. Recently, developed recombinant spider silk proteins ensure constant material properties, as well as scalable production, and further the processing into morphologies other than fibres. Biotechnology enables genetic modification, broadening the range of applications, such as implant coatings, scaffolds for tissue engineering, wound dressing devices as well as drug delivery systems.

PMID:
24657706
DOI:
10.1016/j.copbio.2014.02.015
[Indexed for MEDLINE]

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