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Curr Opin Genet Dev. 2014 Feb;24:38-45. doi: 10.1016/j.gde.2013.11.003. Epub 2013 Dec 27.

Zebrafish models of cancer: progress and future challenges.

Author information

1
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom.
2
Memorial Sloan Kettering Cancer Center and Weill-Cornell Medical College, New York, NY 11788, United States.
3
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom. Electronic address: ds4@sanger.ac.uk.

Abstract

The need for scalable strategies to probe the biological consequences of candidate cancer genes has never been more pressing. The zebrafish, with its capacity for high-throughput transgenesis, in vivo imaging and chemical/genetic screening, has ideal features for undertaking this task. Unique biological insights from zebrafish have already led to the identification of novel oncogenic drivers and small molecules being used to treat the human cancer. This review summarizes the recent main findings and describes pertinent areas where the zebrafish can greatly contribute to our understanding of cancer biology and treatment.

PMID:
24657535
PMCID:
PMC4003353
DOI:
10.1016/j.gde.2013.11.003
[Indexed for MEDLINE]
Free PMC Article
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