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Atherosclerosis. 2014 May;234(1):146-51. doi: 10.1016/j.atherosclerosis.2014.01.015. Epub 2014 Feb 12.

Non-HDL cholesterol is an independent risk factor for aspirin resistance in obese patients with type 2 diabetes.

Author information

1
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, #108 Pyung-Dong, Jongno-Gu, Seoul, Republic of Korea.
2
Division of Endocrinology and Metabolism, Department of Internal Medicine, Gangdong Kyunghee Hospital, Kyunghee University College of Medicine, #892 Dongnam-Ro, Gangdong-Gu, Seoul, Republic of Korea.
3
Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul Saint Mary's Hospital, The Catholic University of Korea College of Medicine, #222 Banpodae-Ro, Seocho-Gu, Seoul, Republic of Korea.
4
Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, #148 Gurodong-Ro, Guro-Gu, Seoul, Republic of Korea.
5
Division of Endocrinology and Metabolism, Department of Internal Medicine, Pyungchon Sacred Heart Hospital, Hallym University College of Medicine, #896 Pyungchon-Dong, Dongan-Gu, Anyang, Gyunggi-Do, Republic of Korea.
6
Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Seoul Hospital, University of Sungkyunkwan College of Medicine, #50 Ilwon-Dong, Gangnam-Gu, Seoul, Republic of Korea.
7
Division of Endocrinology and Metabolism, Department of Internal Medicine, Gil Hospital, Gacheon University College of Medicine, #774-2 Namdongdae-Ro, Namdong-Gu, Incheon, Republic of Korea.
8
Division of Endocrinology and Metabolism, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, #50 Yonsei-Ro, Seodaemun-Gu, Seoul, Republic of Korea.
9
Division of Endocrinology and Metabolism, Department of Internal Medicine, Bucheon Soonchunhyang Hospital, Soonchunhyang University School of Medicine, #170 Jomaru-Ro, Wonmi-Gu, Bucheon, Gyunggi-Do, Republic of Korea.
10
Division of Endocrinology and Metabolism, Department of Internal Medicine, Boramae Hospital, Seoul National University College of Medicine, #20 Boramae-Ro5, Dongjak-Gu, Seoul, Republic of Korea.
11
Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul Asan Hospital, Ulsan University, College of Medicine, #88 Olympic-Ro43, Songpa-Gu, Seoul, Republic of Korea.
12
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, #108 Pyung-Dong, Jongno-Gu, Seoul, Republic of Korea. Electronic address: sungwoo0913.park@samsung.com.

Abstract

OBJECTIVE:

We evaluated the prevalence of aspirin resistance and predictive factors for aspirin resistance in Korean type 2 diabetes patients.

APPROACH AND RESULTS:

A total of 1045 type 2 diabetes patients from 11 hospitals who were taking aspirin (100 mg/day for ≥2 weeks) and no other antiplatelet agents were studied to evaluate aspirin resistance. Aspirin resistance was measured in aspirin reaction units using VerifyNow(®). Aspirin resistance was defined as ≥550 aspirin reaction units. Aspirin resistance was detected in 102 of the 1045 subjects (prevalence 9.8%). Aspirin resistance was associated with total cholesterol (P = 0.013), LDL-cholesterol (P = 0.028), and non-HDL cholesterol (P = 0.008) concentrations in univariate analysis. In multivariate logistic regression analysis, only non-HDL cholesterol was associated with aspirin resistance in obese (BMI >25 kg/m(2)) type 2 diabetes patients (adjusted odds ratio 3.55, 95% CI: 1.25-10.05, P = 0.017).

CONCLUSIONS:

The prevalence of aspirin resistance in Korean type 2 diabetes patients is 9.8%. Non-HDL cholesterol is an independent risk factor for aspirin resistance, especially in obese type 2 diabetes patients.

KEYWORDS:

Aspirin resistance; Atherogenic dyslipidemia; Diabetes; Non-HDL cholesterol

[Indexed for MEDLINE]

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