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J Neuroimmunol. 2014 May 15;270(1-2):56-60. doi: 10.1016/j.jneuroim.2014.02.014. Epub 2014 Mar 6.

Cerebrospinal fluid IL-1β correlates with cortical pathology load in multiple sclerosis at clinical onset.

Author information

1
Multiple Sclerosis Centre of Padova, Department of Neurosciences, University of Padova, via Giustiniani 2, 35128 Padova, Italy.
2
Neurosciences Laboratory, First Neurology Clinic, Department of Neurosciences, University of Padova, via Giustiniani 2, 35128 Padova, Italy.
3
Multiple Sclerosis Centre of Padova, Department of Neurosciences, University of Padova, via Giustiniani 2, 35128 Padova, Italy. Electronic address: paolo.gallo@unipd.it.

Abstract

The cerebrospinal fluid levels of interleukin-1 beta and structural magnetic resonance parameters of cortical damage, i.e., cortical lesion number and volume, and global cortical thickness, were analysed in multiple sclerosis patients at clinical onset. Cerebrospinal fluid interleukin-1 beta levels strongly correlated with cortical lesion load and cortical thickness, while correlation with white matter lesion load was modest. Interleukin-1 beta, intrathecally produced by infiltrating lymphocytes and activated microglia, may constitute a possible link between inflammation and neurodegeneration in multiple sclerosis.

KEYWORDS:

Cortical pathology; Interleukin-1β; Multiple sclerosis

PMID:
24657029
DOI:
10.1016/j.jneuroim.2014.02.014
[Indexed for MEDLINE]

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