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Nutr Metab Cardiovasc Dis. 2014 Jul;24(7):698-704. doi: 10.1016/j.numecd.2014.01.015. Epub 2014 Jan 31.

Flavonoids and arterial stiffness: promising perspectives.

Author information

1
Gérontopôle, Centre Hospitalier Universitaire de Toulouse, France; Service de Gériatrie, Centre Hospitalier Universitaire Bichat, Paris, France. Electronic address: mlilamand@hotmail.fr.
2
Gérontopôle, Centre Hospitalier Universitaire de Toulouse, France.
3
Gérontopôle, Centre Hospitalier Universitaire de Toulouse, France; INSERM UMR 1027, Toulouse, France.
4
Geriatria, Università Campus Bio-Medico, Roma, Italy.
5
Service de Gériatrie, Centre Hospitalier Universitaire Bichat, Paris, France.
6
Gérontopôle, Centre Hospitalier Universitaire de Toulouse, France; INSERM UMR 1027, Toulouse, France; Université de Toulouse III Paul Sabatier, Toulouse, France.

Abstract

BACKGROUND AND AIMS:

Flavonoids are a group of polyphenol compounds, ubiquitously found in plants. Great emphasis has been given to their possible benefits for cardiovascular health. These beneficial effects may be mediated by a specific action on arterial walls. Arterial stiffness is a marker of vascular aging, increasingly used in the clinical setting and assessed by pulse wave velocity. It has shown to be a robust predictor of cardiovascular events and mortality. This review aims at providing a comprehensive evaluation of available intervention and observational studies examining the relationship between flavonoid consumption and arterial stiffness.

DATA SYNTHESIS:

A Medline(®) literature search was performed using the keywords "arterial stiffness" and "flavonoids". As a result, 2 cross-sectional and 16 intervention studies assessing the relationship between flavonoids intake and arterial stiffness were retained. Four intervention trials reported a significant decrease of arterial stiffness after a flavonoid-based intervention, independently from blood pressure changes. The two observational studies reported significant associations between a higher flavonoid consumption and a lower arterial stiffness. In this review, isoflavones, anthocyanins and to a lesser extent cocoa flavan-3-ols appeared to be the more efficient to improve vascular function.

CONCLUSIONS:

Despite their heterogeneity, preliminary data seem to support an improvement of the arterial stiffness related to flavonoid intake. However, further research on absorption and dose-response effects of the specific flavonoid subclasses on arterial structure is warranted.

KEYWORDS:

Arterial stiffness; Cardiovascular diseases; Flavonoids; Wave reflection

PMID:
24656854
DOI:
10.1016/j.numecd.2014.01.015
[Indexed for MEDLINE]

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