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Mater Sci Eng C Mater Biol Appl. 2014 May 1;38:227-34. doi: 10.1016/j.msec.2014.02.007. Epub 2014 Feb 12.

In vitro degradation of porous PLLA/pearl powder composite scaffolds.

Author information

1
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
2
Institut für Physiologische Chemie, University Medical Center, Johannes Gutenberg University Mainz, Universität, Duesbergweg 6, 55099 Mainz, Germany.
3
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China; Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China. Electronic address: biomater@mail.tsinghua.edu.cn.

Abstract

The in vitro degradation behavior of poly-L-lactide (PLLA), PLLA/aragonite pearl powder and PLLA/vaterite pearl powder scaffolds was investigated. The scaffolds were soaked in phosphate buffer solution (PBS) up to 200 days. Scanning electron microscopy (SEM), gel permeation chromatography (GPC), and differential scanning calorimetry (DSC) were used to observe any degradation of the scaffolds. Degradation behaviors such as changes in pH, porosity, bulk density, water absorption, weight loss and mechanical properties were discussed. The results show that a gradual increase of the pH in composite scaffolds can decrease the rate of hydrolysis of PLLA. PLLA/vaterite and PLLA/aragonite scaffolds have a similar degradation behavior but a slower rate of degradation than PLLA.

KEYWORDS:

Aragonite; Composite scaffold; Degradation; PLLA; Vaterite

PMID:
24656373
DOI:
10.1016/j.msec.2014.02.007
[Indexed for MEDLINE]

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