Format

Send to

Choose Destination
See comment in PubMed Commons below
J Affect Disord. 2014 Apr;158:108-13. doi: 10.1016/j.jad.2014.02.014. Epub 2014 Feb 12.

Intolerance of uncertainty mediates reduced reward anticipation in major depressive disorder.

Author information

1
Stony Brook University, Department of Psychology, Stony Brook, NY 11794, United States. Electronic address: bradynelson103@gmail.com.
2
University of Illinois-Chicago, Department of Psychology, 1007 W. Harrison St. (M/C 285), Chicago, IL 60607, United States.
3
Stony Brook University, Department of Psychology, Stony Brook, NY 11794, United States.

Abstract

BACKGROUND:

Reduced reward sensitivity has long been considered a fundamental deficit of major depressive disorder (MDD). One way this deficit has been measured is by an asymmetry in electroencephalogram (EEG) activity between left and right frontal brain regions. MDD has been associated with a reduced frontal EEG asymmetry (i.e., decreased left relative to right) while anticipating reward. However, the mechanism (or mediator) of this association is unclear. The present study examined whether intolerance of uncertainty (IU) mediated the association between depression and reduced reward anticipation.

METHODS:

Data were obtained from a prior study reporting reduced frontal EEG asymmetry while anticipating reward in early-onset MDD. Participants included 156 individuals with early-onset MDD-only, panic disorder-only, both (comorbids), or controls. Frontal EEG asymmetry was recorded during an uncertain reward anticipation task. Participants completed a self-report measure of IU.

RESULTS:

All three psychopathology groups reported greater IU relative to controls. Across all participants, greater IU was associated with a reduced frontal EEG asymmetry. Furthermore, IU mediated the relationship between MDD and frontal EEG asymmetry and results remained significant after controlling for neuroticism, suggesting effects were not due to broad negative affectivity.

LIMITATIONS:

MDD participants were limited to those with early-onset depression. Measures were collected cross-sectionally, precluding causal relationships.

CONCLUSIONS:

IU mediated the relationship between MDD and reduced reward anticipation, independent of neuroticism. Explanations are provided regarding how IU may contribute to reduced reward anticipation in depression. Overall, IU appears to be an important mechanism for the association between depression and reduced reward anticipation.

KEYWORDS:

Anticipation; Depression; Electroencephalography; Intolerance of uncertainty; Reward

PMID:
24655774
PMCID:
PMC3994557
DOI:
10.1016/j.jad.2014.02.014
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center