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Afr J Tradit Complement Altern Med. 2013 Nov 2;11(1):140-147. eCollection 2014.

Assessment of the anti-diarrhea function of compound Chinese herbal medicine Cangpo Oral Liquid.

Author information

1
Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Engineering and Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutics Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730050, Gansu, China.
2
Faculté de Médecine, Université de Bretagne Occidentale, 29238 Brest, France 4 Lanzhou Productivity Promoting Center, Lanzhou 730030. China.
3
Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
#
Contributed equally

Abstract

BACKGROUND:

Diarrhea is a big problem in piglets. Cangpo Oral Liquid (COL) is a compound of Chinese herbal medicine. The preparation was fed to piglets had diarrheal disease in order to determine its anti-diarrhea activity and potential applications in vivo.

MATERIALS AND METHODS:

The contents of Berberine hydrochloride, Magnolol and Honokiol in COL were performed on HPLC analysis. Organ bath was used to investigate the effect of COL on peristaltic reflexes and peristaltic waves in vitro. And anti-diarrhea activity of COL was evaluated in clinical.

RESULTS:

Thin layer chromatography (TLC) and HPLC analyses showed that the contents of Berberine hydrochloride, Magnolol and Honokiol in COL were 970µg/mL, 130µg/mL and 300µg/mL, respectively. Administration of the COL to the organ bath caused a concentration-dependent inhibition of intestinal peristalsis. When the COL concentration in the bath was cumulatively increased, the amplitude and frequency of the peristaltic waves was lowered. The result of clinical efficacy of COL was very effective to diarrheic piglets. COL can possibly inhibit the curve of peristaltic waves in vitro; and clinical trial showed a statistically significant therapeutic effect in vivo.

CONCLUSION:

In conclusion, COL can be used as an effective therapeutic agent. However, the ingredients, pharmacokinetics and specific signaling pathways of COL need to be further studied.

KEYWORDS:

Cangpo Oral Liquid; herbal; peristalsis; therapeutic effect

PMID:
24653568
PMCID:
PMC3957256
[Indexed for MEDLINE]
Free PMC Article

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