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J Infect Dis. 2014 Aug 15;210(4):651-5. doi: 10.1093/infdis/jiu176. Epub 2014 Mar 20.

Long-term effect of depot medroxyprogesterone acetate on vaginal microbiota, epithelial thickness and HIV target cells.

Author information

1
Department of Obstetrics and Gynecology Fred Hutchinson Cancer Research Center, Vaccine and Infectious Diseases Division, Seattle, Washington.
2
Department of Obstetrics and Gynecology.
3
Fred Hutchinson Cancer Research Center, Vaccine and Infectious Diseases Division, Seattle, Washington.
4
Department of Internal Medicine II, University Hospital, Regensburg, Germany.
5
Department of Laboratory Medicine Fred Hutchinson Cancer Research Center, Vaccine and Infectious Diseases Division, Seattle, Washington.
6
Department of Laboratory Medicine Department of Medicine, Division of Allergy and Infectious Diseases Department of Global Health, University of Washington Fred Hutchinson Cancer Research Center, Vaccine and Infectious Diseases Division, Seattle, Washington.
7
Department of Obstetrics and Gynecology Department of Medicine, Division of Allergy and Infectious Diseases Fred Hutchinson Cancer Research Center, Vaccine and Infectious Diseases Division, Seattle, Washington.

Abstract

BACKGROUND:

Depot medroxyprogesterone acetate (DMPA) has been linked to human immunodeficiency virus type 1 (HIV-1) acquisition.

METHODS:

Vaginal microbiota of women using DMPA for up to 2 years were cultured. Mucosal immune cell populations were measured by immunohistological staining.

RESULTS:

Over 12 months, the proportion with H2O2-positive lactobacilli decreased (n = 32; 53% vs 27%; P = .03). Median vaginal CD3(+) cells also decreased (n = 15; 355 vs 237 cells/mm(2); P = .03), as did CD3(+)CCR5(+) cells (195 vs 128 cells/mm(2); P = .04), HLA-DR(+) cells (130 vs 96 cells/mm(2); P = .27), and HLA-DR(+)CCR5(+) cells (18 vs 10 cells/mm(2); P = .33).

CONCLUSIONS:

DMPA contraception does not increase vaginal mucosal CCR5(+) HIV target cells but does decrease CD3(+) T lymphocytes and vaginal H2O2-producing lactobacilli.

KEYWORDS:

HIV; medroxyprogesterone acetate; vaginal mucosa

PMID:
24652495
PMCID:
PMC4172039
DOI:
10.1093/infdis/jiu176
[Indexed for MEDLINE]
Free PMC Article

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