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Biomedica. 2013 Sep;33 Suppl 1:22-30.

[Dengue virus serotype 1 (DENV-1) from Colombia: its contribution to dengue occurrence in Santander].

[Article in Spanish]

Author information

1
Laboratorio de Arbovirus, Centro de Investigaciones en Enfermedades Tropicales, Universidad Industrial de Santander, Bucaramanga, Colombia.
2
Laboratorio de Sistemática y Biogeografía, Escuela de Biología, Universidad Industrial de Santander.

Abstract

INTRODUCTION:

Between 1998 and 2008 all dengue virus serotypes circulated in the Departamento de Santander, an endemic region in northeastern Colombia. No information is available as to the role of serotype 1 (DENV-1) with respect to epidemiology of dengue.

OBJECTIVE:

To analyze the relationship between changes in DENV-1 predominance with respect to genetic diversity, prevalence of others serotypes and occurrence of severe dengue.

METHODS:

Virus genetic diversity was studied by phylogenetic analysis comparing E gene sequences from 12 viral strains. Data about serotypes predominance obtained in previous studies and official data about dengue incidence were used for analysis.

RESULTS:

Selected viruses grouped into genotype V together DENV-1 from Latin America countries, and segregation in four lineages was evidenced. Changes in virus predominance coincided with replacement of lineage, increase in prevalence of DENV-2 and DENV-3 and increase of severe dengue.

CONCLUSION:

Genetic divergence could have contributed to changes in DENV-1 predominance. The relationship of the virus with DENV-2 and DENV-3 could create scenarios that promote occurrence of severe cases. More studies are required to ascertain the precise role of serotypes in the epidemiology of dengue.

PMID:
24652246
[Indexed for MEDLINE]

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