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Bioinformatics. 2014 Aug 1;30(15):2237-8. doi: 10.1093/bioinformatics/btu155. Epub 2014 Mar 20.

OncomiRDB: a database for the experimentally verified oncogenic and tumor-suppressive microRNAs.

Author information

1
MOE Key Laboratory of Bioinformatics, TNLIST Bioinformatics Division / Center for Synthetic and Systems Biology, Department of Automation, Tsinghua University, Beijing 100084, China.

Abstract

SUMMARY:

MicroRNAs (miRNAs), a class of small regulatory RNAs, play important roles in cancer initiation, progression and therapy. MiRNAs are found to regulate diverse cancer-related processes by targeting a large set of oncogenic and tumor-suppressive genes. To establish a high-confidence reference resource for studying the miRNA-regulated target genes and cellular processes in cancer, we manually curated 2259 entries of cancer-related miRNA regulations with direct experimental evidence from ∼9000 abstracts, covering more than 300 miRNAs and 829 target genes across 25 cancer tissues. A web-based portal named oncomiRDB, which provides both graphical and text-based interfaces, was developed for easily browsing and searching all the annotations. It should be a useful resource for both the computational analysis and experimental study on miRNA regulatory networks and functions in cancer.

AVAILABILITY AND IMPLEMENTATION:

http://bioinfo.au.tsinghua.edu.cn/oncomirdb/

CONTACT:

jgu@tsinghua.edu.cn

SUPPLEMENTARY INFORMATION:

Supplementary data are available at Bioinformatics online.

PMID:
24651967
DOI:
10.1093/bioinformatics/btu155
[Indexed for MEDLINE]

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