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Cancer Cell. 2014 Mar 17;25(3):304-17. doi: 10.1016/j.ccr.2014.01.021.

Mutant p53 in cancer: new functions and therapeutic opportunities.

Author information

1
Medical Research Council Toxicology Unit, Hodgkin Building, Lancaster Road, Leicester LE1 9HN, UK. Electronic address: pm292@le.ac.uk.
2
CR-UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. Electronic address: k.vousden@beatson.gla.ac.uk.

Abstract

Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types.

PMID:
24651012
PMCID:
PMC3970583
DOI:
10.1016/j.ccr.2014.01.021
[Indexed for MEDLINE]
Free PMC Article

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