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Cancer Cell. 2014 Mar 17;25(3):263-5. doi: 10.1016/j.ccr.2014.02.022.

Leukemia propagating cells Akt up.

Author information

1
Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA. Electronic address: alejandro.gutierrez@childrens.harvard.edu.
2
Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
3
Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: michelle.kelliher@umassmed.edu.

Abstract

Individual cancer cells can exhibit striking differences in tumorigenic potential following experimental transplantation, but the molecular pathways that regulate this activity remain poorly understood. In this issue of Cancer Cell, Blackburn and colleagues report that Akt signaling regulates both leukemia-propagating potential and proliferation rate via distinct pathways in T-ALL.

PMID:
24651006
DOI:
10.1016/j.ccr.2014.02.022
[Indexed for MEDLINE]
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