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Curr Opin Neurobiol. 2014 Jun;26:42-50. doi: 10.1016/j.conb.2013.12.006. Epub 2013 Dec 28.

Endogenous cannabinoid signaling at inhibitory interneurons.

Author information

1
Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, United States.
2
Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, United States. Electronic address: pablo.castillo@einstein.yu.edu.

Abstract

Significant progress has been made in our understanding of how endogenous cannabinoids (eCBs) signal at excitatory and inhibitory synapses in the central nervous system (CNS). This review discusses how eCBs regulate inhibitory interneurons, their synapses, and the networks in which they are embedded. eCB signaling plays a pivotal role in brain physiology by means of their synaptic signal transduction, spatiotemporal signaling profile, routing of information through inhibitory microcircuits, and experience-dependent plasticity. Understanding the normal processes underlying eCB signaling is beginning to shed light on how their dysregulation contributes to disease.

PMID:
24650503
PMCID:
PMC4024354
DOI:
10.1016/j.conb.2013.12.006
[Indexed for MEDLINE]
Free PMC Article

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