Send to

Choose Destination
See comment in PubMed Commons below
Mol Clin Oncol. 2013 Jan;1(1):53-58. Epub 2012 Sep 7.

Differentiation between sessile serrated adenoma/polyp and non-sessile serrated adenoma/polyp in large hyper plastic polyp: A Japanese collaborative study.

Author information

  • 1Departments of Surgery 1 and ; Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Mibu;
  • 2Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Mibu;
  • 3Takahiro Fujii Clinic, Tokyo;
  • 4Endoscopy Division, Gastrointestinal Center, Sano Hospital, Kobe;
  • 5Oda GI Clinic;
  • 6Hattori GI Endoscopy and Oncology Clinic, Kumamoto;
  • 7Ohta Clinic, Tokyo;
  • 8Department of Endoscopy, Hiroshima University Hospital, Hiroshima;
  • 9Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University, Morioka;
  • 10Department of Human Pathology, Juntendo University School of Medicine;
  • 11Department of Pathology, Kyorin University School of Medicine, Tokyo;
  • 12Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, Japan.
  • 13Departments of Surgery 1 and.


A hyperplastic polyp (HP) >10 mm is described as a large hyperplastic polyp (LHP). Previous studies have considered LHP and sessile serrated adenoma/polyp (SSA/P) as synonymous. Although HP and SSA/P have previously been morphologically distinguished, differences between LHP and SSA/P have not yet been reported. The present study aimed to define the differences between SSA/P and non-SSA/P in LHP using immunohistochemistry for Ki67. Colorectal serrated lesions (>10 mm) that were completely resected by endoscope and derived from 11 institutions in Japan [Dokkyo Medical University School of Medicine (Mibu), Takahiro Fujii Clinic (Tokyo), Sano Hospital (Kobe), Oda GI Clinic, Hattori GI Endoscopy and Oncology Clinic (Kumamoto), Ohta Clinic (Nagoya), Hiroshima University (Hiroshima), Iwate Medical University (Morioka), Juntendo and Kyorin Universities (Tokyo) as well as Toyama University (Toyama)] affiliated with the Japanese Society for Cancer of the Colon and Rectum (JSCCR) between January 2003 and December 2010 were selected. The histological criteria of the Japanese Society for Cancer of the Colon and Rectum (JSCCR, project meeting; editor-in chief, Takashi Yao) were used to distinguish SSA/P and non-SSA/P from LHP. Non-SSA/P comprises both incomplete SSA/P and HP. A total of 154 samples diagnosed as SSA/P or non-SSA/P from 148 patients were used. This study comprised 107 SSA/P and 47 non-SSA/P cases, whereby lesions were located on the right side of the colon (73.2 and 26.8%, respectively). Ki67-positivity in SSA/Ps was significantly higher compared to non-SSA/Ps. A greater number of SSA/Ps in LHP were located on the right side of the colon compared to the left side. SSA/Ps occurring on the right side of the colon may be precursor lesions of colorectal carcinoma in serrated neoplasia pathways. In conclusion, LHPs and SSA/Ps limited to the right side of the colon are suggested to be clinically treated as the same type of lesions.


Ki67; large hyperplastic polyp; sessile serrated adenoma/polyp; tumor location

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center