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Biomed Rep. 2013 Nov;1(6):837-839. Epub 2013 Sep 12.

The emerging role of interleukin-21 in allergic diseases (Review).

Author information

1
Department of Laboratory Medicine, The Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu 214041, P.R. China.
2
Department of Pulmonary Medicine, Allergy and Clinical Immunology, The Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu 214041, P.R. China.

Abstract

Interleukin (IL)-21 is a newly discovered member of the type I cytokine family. Since its discovery in 2000, IL-21 has been the focus of extensive investigation, due to its homology to IL-2, IL-4 and IL-15 and its pleiotropic effects on innate and adaptive immune responses. An increasing amount of experimental evidence supports a role for IL-21 in the pathogenesis of several allergic diseases, such as allergic rhinitis, atopic dermatitis (AD) and atopic asthma. In this review, we aimed to discuss the biological characteristics of IL-21 and summarize the current progress on the role of IL-21 in the regulation of allergic inflammation.

KEYWORDS:

allergic rhinitis; atopic asthma; atopic dermatitis; interleukin-21

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