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Dis Markers. 2014;2014:472624. doi: 10.1155/2014/472624. Epub 2014 Feb 4.

Soluble IL-2 receptor: a biomarker for assessing myositis activity.

Author information

1
Department of Rheumatology, CHU Clermont-Ferrand, Hôpital Gabriel Montpied, 63003 Clermont-Ferrand, France.
2
Department of Internal Medicine, CHU Clermont-Ferrand, Hôpital Estaing, 63003 Clermont-Ferrand, France.
3
Department of Dermatology, CHU Clermont-Ferrand, Hôpital Estaing, 63003 Clermont-Ferrand, France.
4
Emergency Department, CHU Clermont-Ferrand, Hôpital Gabriel Montpied, 63003 Clermont-Ferrand, France.
5
Department of Neurology, CHU Clermont-Ferrand, Hôpital Gabriel Montpied, 63003 Clermont-Ferrand, France.
6
Immunology Laboratory, Faculty of Pharmacy, 63003 Clermont-Ferrand, France.

Abstract

OBJECTIVE:

To evaluate the clinical significance of serum soluble IL-2R (sIL-2R) in inflammatory myopathies.

METHODS:

Serum sIL-2R and CK levels were determined in 27 patients with IM during periods of disease exacerbation and inactive disease and were compared to 20 healthy controls and 23 controls with noninflammatory elevated CK. The performance of sIL-2R and CK tests for assessing disease activity was compared.

RESULTS:

sIL-2R levels were increased in patients with IM. Significantly higher sIL-2R levels were detected in patients with disease exacerbation than in patients with inactive disease. In patients with IM, the sIL-2R levels correlated with the CK levels. Based on ROC analysis, diagnostic accuracy of sIL-2R and CK tests for disease activity was similar. However, when the CK threshold was defined by the upper limit of the normal, the specificity for the CK test dropped to 58%.

CONCLUSION:

Serum sIL-2R level could be useful to distinguish disease exacerbation from damage in IM, especially in patients with persistent elevated CK levels when a clinical muscular worsening is noted. For discrimination of the disease activity, CK testing requires the use of a different threshold than the upper limit of the normal.

PMID:
24648607
PMCID:
PMC3932274
DOI:
10.1155/2014/472624
[Indexed for MEDLINE]
Free PMC Article
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