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J Evid Based Complementary Altern Med. 2014 Jul;19(3):176-180. Epub 2014 Mar 19.

Antiulcer Effect of Extract/Fractions of Eruca sativa : Attenuation of Urease Activity.

Author information

1
Department of Pharmacy, Adbul Wali Khan University, Mardan, Pakistan hkdr2006@gmail.com.
2
Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.

Abstract

Eruca sativa (Rocket salad) is known for its antiulcer properties in the traditional system of treatment. The present study was, therefore, designed to scrutinize its effect on urease activity in vitro. The results demonstrated marked attenuation of urease by the crude extract of various test concentrations with IC50 value of 7.77 mg/mL. On fractionation, marked change in inhibitory profile was observed. The ethyl acetate fraction was the most potent urease inhibitor with IC50 value of 4.17 mg/mL followed by the aqueous fraction with an IC50 value of 5.83 mg/mL. However, hexane did not show significant urease inhibition. In conclusion, the present study illustrated strong antagonism of urease activity and thus validated scientifically the traditional use of the plant in the treatment of ulcers.

KEYWORDS:

Eruca sativa ; extract/fractions; urease inhibition

PMID:
24647097
DOI:
10.1177/2156587214527452

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