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Nat Immunol. 2014 Apr;15(4):319-22. doi: 10.1038/ni.2844.

Vaccines that stimulate T cell immunity to HIV-1: the next step.

Author information

1
Nuffield Department of Medicine, Oxford University, Oxford, UK.
2
International AIDS Vaccine Initiative, New York, New York, USA.

Abstract

The search for a vaccine against human immunodeficiency virus type 1 (HIV-1) has many hurdles to overcome. Ideally, the stimulation of both broadly neutralizing antibodies and cell-mediated immune responses remains the best option, but no candidate in clinical trials at present has elicited such antibodies, and efficacy trials have not demonstrated any benefit for vaccines designed to stimulate immune responses of CD8(+) T cells. Findings obtained with the simian immunodeficiency virus (SIV) monkey model have provided new evidence that stimulating effective CD8(+) T cell immunity could provide protection, and in this Perspective we explore the path forward for optimizing such responses in humans.

PMID:
24646598
PMCID:
PMC4324504
DOI:
10.1038/ni.2844
[Indexed for MEDLINE]
Free PMC Article

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