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J Nephropathol. 2014 Jan;3(1):4-8. doi: 10.12860/jnp.2014.02. Epub 2014 Jan 1.

What nephrolopathologists need to know about antiphospholipid syndrome-associated nephropathy: Is it time for formulating a classification for renal morphologic lesions?

Author information

1
Department of Histopathology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan.
2
Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

CONTEXT:

Antiphospholipid syndrome (APS) is a systemic autoimmune disorder which commonly affects kidneys.

EVIDENCE ACQUISITIONS:

Directory of Open Access Journals (DOAJ), Google Scholar, PubMed (NLM), LISTA (EBSCO) and Web of Science have been searched.

RESULTS:

There is sufficient epidemiological, clinical and histopathological evidence to show that antiphospholipid syndrome is a distinctive lesion caused by antiphospholipid antibodies in patients with different forms of antiphospholipid syndrome. It is now time to devise a classification for an accurate diagnosis and prognostication of the disease.

CONCLUSIONS:

Now that the morphological lesions of APSN are sufficiently well characterized, it is prime time to devise a classification which is of diagnostic and prognostic utility in this disease.

KEYWORDS:

APS-associated nephropathy; Antiphospholipid syndrome; Systemic lupus erythematosus; Thrombotic microangiopathy

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